The IUSCCC Biospecimen Collection and Banking Core (BC2) offers services related to biospecimen and data collection in support of cancer research. It contains four distinct service lines, each with its own specialty including: • the Tissue Procurement and Distribution Core • the Komen Tissue Bank (the only known global biorepository that collects, stores, and annotates healthy breast tissue and blood to be used in research); • the Oncology Research Information Exchange Network (ORIEN; a national consortium of cancer centers dedicated to accelerating cancer research); • the Clinical Trials Office (CTO) Biospecimen Lab Tech group (providing specimen collection/distribution support] The core, which is led by Anna Maria Storniolo, MD, provides an extensive collection of well-annotated samples from patients to support studies exploring the biologic basis of cancer, move basic findings to the clinic, and probe the biology underlying clinical and population phenomena.